Abcb11 (GeneName), Bile salt export pump (ProteinName), ABCBB_RAT.
Product Name:
Rat Abcb11/ Bile salt export pump ELISA Kit
Cat.#:
E10415r
Brand:
EIAab®
Regulatory Status:
Alternative:
ATP-binding cassette sub-family B member 11, Sister of P-glycoprotein, Bsep, Spgp
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
78-5000pg/mL
Sensitivity:
32pg/mL
Specificity:
Natural and recombinant rat Bile salt export pump
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
Cardiovascular
- Data
- Citations
- Publication
- Sequence / 3D
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Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤3.8%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤6.5%
Recovery
Recovery was determined by spiking various levels of Bile salt export pump into serum and plasma.
|
Sample Type |
Average(%) |
Recovery Range(%) |
|
Serum |
103 |
97-109 |
|
Plasma |
105 |
99-111 |
Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Bile salt export pump and their serial dilutions.
The results were demonstrated by the percentage of calculated concentration to the expected.
|
Sample |
1：2 |
1:4 |
1:8 |
1:16 |
|
serum(n=5) |
96-105% |
92-104% |
102-113% |
103-112% |
|
EDTA plasma(n=5) |
85-95% |
96-107% |
103-113% |
80-91% |
|
heparin plasma(n=5) |
89-99%
|
109-119% |
113-123% |
106-114% |
General Annotation
Sub Unit:
Interacts with HAX1.
Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Subcellular Location:
Membrane
Multi-pass membrane protein
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury."
[2].
"Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy."
[3].
"A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis."
[4].
"Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability."
[5].
"Common variants of ABCB4 and ABCB11 and plasma lipid levels: a study in sib pairs with gallstones, and controls."
[6].
"Genetic variability, haplotype structures, and ethnic diversity of hepatic transporters MDR3 (ABCB4) and bile salt export pump (ABCB11)."
[7].
"Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis."
[8].
"BSEP and MDR3 haplotype structure in healthy Caucasians, primary biliary cirrhosis and primary sclerosing cholangitis."
[9].
"FIC1 and BSEP defects in Taiwanese patients with chronic intrahepatic cholestasis with low gamma-glutamyltranspeptidase levels."
[10].
"Diagnosis of ABCB11 gene mutations in children with intrahepatic cholestasis using high resolution melting analysis and direct sequencing."
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