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Abcb5 (GeneName), ATP-binding cassette sub-family B member 5 (ProteinName), ABCB5_MOUSE.
Product Name:

Mouse Abcb5/ ATP-binding cassette sub-family B member 5 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

ABCB5 P-gp, P-glycoprotein ABCB5

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse ATP-binding cassette sub-family B member 5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Abcb5 ELISA Kit
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Mouse Abcb5 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.


Subcellular Location:
Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter."

[2].
"ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit."

[3].
"ABCB5 is a limbal stem cell gene required for corneal development and repair."

[4].
"Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk."

[5].
"Expression of ABCB5 gene in hematological malignances and its significance."
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