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Home  >  ELISA Kit  >  Human ABCB5 ELISA Kit
ABCB5 (GeneName), ATP-binding cassette sub-family B member 5 (ProteinName), ABCB5_HUMAN.
Product Name:

Human ABCB5/ ATP-binding cassette sub-family B member 5 ELISA Kit

Cat.#:

E10410h

Brand:
EIAab®
Regulatory Status:
Alternative:

ABCB5 P-gp, P-glycoprotein ABCB5

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.098ng/mL
Specificity:
Natural and recombinant human ATP-binding cassette sub-family B member 5
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Cancer
Human ABCB5 ELISA Kit
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Human ABCB5 ELISA Kit
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Product Datasheets
Datasheet: Down Datasheet
Instruction: Down Instruction
MSDS: MSDS


Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤5.1%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤6.8%

Recovery
Recovery was determined by spiking various levels of ATP-binding cassette sub-family B member 5 into serum and plasma.

Sample Type

Average(%)

Recovery Range(%)

Serum

85

80-91

Plasma

87

81-93

 

 

 

 

Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ATP-binding cassette sub-family B member 5 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

84-97%

104-114%

80-91%

86-96%

EDTA plasma(n=5)

99-108%

100-109%

92-101%

101-110%

heparin plasma(n=5)

103-115%

 

110-120%

90-99%

105-117%

 

General Annotation


Sub Unit:
N/A


Function:
Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.


Subcellular Location:
Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter."

[2].
"ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit."

[3].
"ABCB5 is a limbal stem cell gene required for corneal development and repair."

[4].
"Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk."

[5].
"Expression of ABCB5 gene in hematological malignances and its significance."
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