Home > ELISA Kit > Rat Abca7 ELISA Kit

Abca7 (GeneName), ATP-binding cassette sub-family A member 7 (ProteinName), ABCA7_RAT.

Product Name:

Rat Abca7/ ATP-binding cassette sub-family A member 7 ELISA Kit

Cat.#:

E15004r

Brand:

EIAab^®

Regulatory Status:

RUO

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

0.156-10ng/mL

Sensitivity:

0.061ng/mL

Specificity:

Natural and recombinant rat ATP-binding cassette sub-family A member 7

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

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Rat Abca7 ELISA Kit

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Product Datasheets

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
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Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.8%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.5%

Recovery

Recovery was determined by spiking various levels of ATP-binding cassette sub-family A member 7 into serum and plasma.

Sample Type	Average(%)	Recovery Range(%)
Serum	84	80-90
Plasma	86	80-92

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ATP-binding cassette sub-family A member 7 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	100-109%	111-120%	106-116%	105-115%
EDTA plasma(n=5)	101-112%	90-100%	90-100%	99-109%
heparin plasma(n=5)	106-116%	105-115%	100-110%	103-113%

General Annotation

Sub Unit:

N/A

Function:

Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation.

Subcellular Location:

Cell membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Endosome membrane Multi-pass membrane protein Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney.

Database link

UniGene:

Rn.25281

STRING:

10116.ENSRNOP00000063805

KEGG:

rno:299609

Pfam:

PF00005

Uniprot:

Q7TNJ2

Related Product

Human ABCA7 ELISA Kit

Mouse Abca7 ELISA Kit

Human ABCA7 CLIA Kit

Mouse Abca7 CLIA Kit

Human ABCA7 Protein

Sequence length:

2170

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2170:

QHPKRVSRFL | EDPSSVETVI |

3D Structure:

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Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein."

(PMID: 14570867)

[2].

"Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7)."

(PMID: 10873640)

[3].

"Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease."

(PMID: 25807283)

[4].

"Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study."

(PMID: 26141617)

[5].

"Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease."

(PMID: 21460840)

[6].

"Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease."

(PMID: 21460841)

[7].

"Genetic susceptibility to distinct bladder cancer subphenotypes."

(PMID: 19692168)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease."

(PMID: 20855565)

[10].

"Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China."

(PMID: 19170196)

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