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首页  >  酶联免疫试剂盒  >  Human ABCA4 ELISA Kit
ABCA4 (基因名), Retinal-specific phospholipid-transporting ATPase ABCA4 (蛋白名), ABCA4_HUMAN.
产品名称:

Human ABCA4/ Retinal-specific phospholipid-transporting ATPase ABCA4 ELISA Kit
视网膜特异性磷脂转运atp酶ABCA4

货号:

E10399h

商标:
EIAab®
监管等级:
别名:

ATP-binding cassette sub-family A member 4, RIM ABC transporter, RIM protein, ABCR, Retinal-specific ATP-binding cassette transporter, Stargardt disease protein

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
38pg/mL
特异性:
Natural and recombinant human Retinal-specific phospholipid-transporting ATPase ABCA4
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human ABCA4 ELISA Kit
规格 & 价格: cart
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Human ABCA4 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS


线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

103-116%

97-107%

108-116%

95-105%

EDTA plasma(n=5)

99-108%

91-103%

87-97%

97-107%

heparin plasma(n=5)

86-98%

 

105-114%

91-103%

84-94%

 

通用注释


亚单元:
N/A


功能:
Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylethanolamine (PubMed:24097981). In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery.


亚细胞位置:
Membrane Multi-pass membrane protein Endoplasmic reticulum Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor.


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