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APOBEC3H (基因名), DNA dC->dU-editing enzyme APOBEC-3H (蛋白名), ABC3H_HUMAN.
产品名称:

Human APOBEC3H/ DNA dC->dU-editing enzyme APOBEC-3H ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

APOBEC-related protein 10, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H, ARP-10, A3H

检测方法:
ELISA
特异性:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3H
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human APOBEC3H ELISA Kit
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Human APOBEC3H ELISA Kit
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通用注释


亚单元:
Interacts with AGO1, AGO2 and AGO3.


功能:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.


亚细胞位置:
Nucleus Cytoplasm Cytoplasm P-body Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.


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