APOBEC3H (GeneName), DNA dC->dU-editing enzyme APOBEC-3H (ProteinName), ABC3H_HUMAN.
Human APOBEC3H/ DNA dC->dU-editing enzyme APOBEC-3H ELISA Kit
APOBEC-related protein 10, ARP-10, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H, A3H
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3H
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with AGO1, AGO2 and AGO3.
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Nucleus Cytoplasm Cytoplasm P-body Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
MALLTAETFR | LQFNNKRRLR | RPYYPRKALL | CYQLTPQNGS | TPTRGYFENK |
KKCHAEICFI | NEIKSMGLDE | TQCYQVTCYL | TWSPCSSCAW | ELVDFIKAHD |
HLNLGIFASR | LYYHWCKPQQ | KGLRLLCGSQ | VPVEVMGFPK | FADCWENFVD |
HEKPLSFNPY | KMLEELDKNS | RAIKRRLERI | KIPGVRAQGR | YMDILCDAEV |
This product has not yet been referenced specifically in any publications.
"Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H."
"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages."
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
"Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity."
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
"APOBEC3 proteins mediate the clearance of foreign DNA from human cells."
"Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."
"Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1."
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