APOBEC3H (GeneName), DNA dC->dU-editing enzyme APOBEC-3H (ProteinName), ABC3H_HUMAN.
Product Name:
Human APOBEC3H/ DNA dC->dU-editing enzyme APOBEC-3H ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
APOBEC-related protein 10, ARP-10, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H, A3H
Detection Method:
ELISA
Specificity:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3H
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Interacts with AGO1, AGO2 and AGO3.
Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.
Subcellular Location:
Nucleus
Cytoplasm
Cytoplasm
P-body
Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
Database link
UniGene:
SMR:
STRING:
KEGG:
MIM:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H."
[2].
"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages."
[3].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
[4].
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."
[5].
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
[6].
"Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity."
[7].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
[9].
"Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction."
[10].
"Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1."
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