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首页  >  酶联免疫试剂盒  >  Human APOBEC3F ELISA Kit
APOBEC3F (基因名), DNA dC->dU-editing enzyme APOBEC-3F (蛋白名), ABC3F_HUMAN.
产品名称:

Human APOBEC3F/ DNA dC->dU-editing enzyme APOBEC-3F ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F, A3F

检测方法:
ELISA
特异性:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3F
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human APOBEC3F ELISA Kit
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Human APOBEC3F ELISA Kit
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产品说明书


通用注释


亚单元:
Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with AGO1, AGO2 and AGO3.


功能:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.


亚细胞位置:
Cytoplasm Cytoplasm P-body


该产品尚未在任何出版物中被引用。

[1].
"APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G."

[2].
"Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies."

[3].
"A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins."

[4].
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."

[5].
"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages."

[6].
"Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n."

[7].
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."

[8].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."

[9].
"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."

[10].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
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