APOBEC3F (基因名), DNA dC->dU-editing enzyme APOBEC-3F (蛋白名), ABC3F_HUMAN.
Human APOBEC3F/ DNA dC->dU-editing enzyme APOBEC-3F ELISA Kit
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F, A3F
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3F
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Binds HIV-1 Vif. In the absence of Vif protein, specifically packaged into HIV-1 virions. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with AGO1, AGO2 and AGO3.
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Cytoplasm Cytoplasm P-body
MKPHFRNTVE | RMYRDTFSYN | FYNRPILSRR | NTVWLCYEVK | TKGPSRPRLD |
AKIFRGQVYS | QPEHHAEMCF | LSWFCGNQLP | AYKCFQITWF | VSWTPCPDCV |
AKLAEFLAEH | PNVTLTISAA | RLYYYWERDY | RRALCRLSQA | GARVKIMDDE |
EFAYCWENFV | YSEGQPFMPW | YKFDDNYAFL | HRTLKEILRN | PMEAMYPHIF |
YFHFKNLRKA | YGRNESWLCF | TMEVVKHHSP | VSWKRGVFRN | QVDPETHCHA |
ERCFLSWFCD | DILSPNTNYE | VTWYTSWSPC | PECAGEVAEF | LARHSNVNLT |
IFTARLYYFW | DTDYQEGLRS | LSQEGASVEI | MGYKDFKYCW | ENFVYNDDEP |
FKPWKGLKYN | FLFLDSKLQE | ILE
"APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G."
"Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies."
"A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins."
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."
"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages."
"Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n."
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
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