APOBEC3D (GeneName), DNA dC->dU-editing enzyme APOBEC-3D (ProteinName), ABC3D_HUMAN.
Product Name:
Human APOBEC3D/ DNA dC->dU-editing enzyme APOBEC-3D ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
A3D
Detection Method:
ELISA
Specificity:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3D
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
Subcellular Location:
Cytoplasm
Cytoplasm
P-body
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."
[2].
"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages."
[3].
"Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n."
[4].
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
[5].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
[6].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
[8].
"The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."
[9].
"Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business."
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