APOBEC3D (GeneName), DNA dC->dU-editing enzyme APOBEC-3D (ProteinName), ABC3D_HUMAN.
Human APOBEC3D/ DNA dC->dU-editing enzyme APOBEC-3D ELISA Kit
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3D
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
Cytoplasm Cytoplasm P-body
MNPQIRNPME | RMYRDTFYDN | FENEPILYGR | SYTWLCYEVK | IKRGRSNLLW |
DTGVFRGPVL | PKRQSNHRQE | VYFRFENHAE | MCFLSWFCGN | RLPANRRFQI |
TWFVSWNPCL | PCVVKVTKFL | AEHPNVTLTI | SAARLYYYRD | RDWRWVLLRL |
HKAGARVKIM | DYEDFAYCWE | NFVCNEGQPF | MPWYKFDDNY | ASLHRTLKEI |
LRNPMEAMYP | HIFYFHFKNL | LKACGRNESW | LCFTMEVTKH | HSAVFRKRGV |
FRNQVDPETH | CHAERCFLSW | FCDDILSPNT | NYEVTWYTSW | SPCPECAGEV |
AEFLARHSNV | NLTIFTARLC | YFWDTDYQEG | LCSLSQEGAS | VKIMGYKDFV |
SCWKNFVYSD | DEPFKPWKGL | QTNFRLLKRR | LREILQ
This product has not yet been referenced specifically in any publications.
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."
"APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages."
"Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n."
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
"APOBEC3 proteins mediate the clearance of foreign DNA from human cells."
"The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements."
"Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business."
"Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif."
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