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首页  >  酶联免疫试剂盒  >  Human APOBEC3C ELISA Kit
APOBEC3C (基因名), DNA dC->dU-editing enzyme APOBEC-3C (蛋白名), ABC3C_HUMAN.
产品名称:

Human APOBEC3C/ DNA dC->dU-editing enzyme APOBEC-3C ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

A3C, APOBEC1-like, Phorbolin I, APOBEC1L, PBI

检测方法:
ELISA
特异性:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3C
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Epigenetics
Human APOBEC3C ELISA Kit
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Human APOBEC3C ELISA Kit
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产品说明书


通用注释


亚单元:
Homodimer. Interacts with human foamy virus protein Bet; this interaction does not induce APOBEC3C degradation, but prevents dimerization and incorporation into virion of the latter. Interacts with TRIB3 and AGO2.


功能:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.


亚细胞位置:
Nucleus Cytoplasm


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