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APOBEC3B (GeneName), DNA dC->dU-editing enzyme APOBEC-3B (ProteinName), ABC3B_HUMAN.
Product Name:

Human APOBEC3B/ DNA dC->dU-editing enzyme APOBEC-3B ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

A3B, Phorbolin-1-related protein, Phorbolin-2/3

Detection Method:
ELISA
Specificity:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3B
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human APOBEC3B ELISA Kit
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Human APOBEC3B ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homodimer. Interacts with APOBEC3G. Does not interact with APOBEC1.


Function:
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.


Subcellular Location:
Nucleus


This product has not yet been referenced specifically in any publications.

[1].
"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."

[2].
"APOBEC3B deletion and risk of HIV-1 acquisition."

[3].
"Population stratification of a common APOBEC gene deletion polymorphism."

[4].
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."

[5].
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."

[6].
"Retroelements versus APOBEC3 family members: No great escape from the magnificent seven."

[7].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."

[8].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."

[9].
"APOBEC3 proteins mediate the clearance of foreign DNA from human cells."

[10].
"No evidence of an association between the APOBEC3B deletion polymorphism and susceptibility to HIV infection and AIDS in Japanese and Indian populations."
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