APOBEC3A (GeneName), DNA dC->dU-editing enzyme APOBEC-3A (ProteinName), ABC3A_HUMAN.
Human APOBEC3A/ DNA dC->dU-editing enzyme APOBEC-3A ELISA Kit
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3A
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with AGO2. Interacts with TRIB3 (via N-terminus).
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
MEASPASGPR | HLMDPHIFTS | NFNNGIGRHK | TYLCYEVERL | DNGTSVKMDQ |
HRGFLHNQAK | NLLCGFYGRH | AELRFLDLVP | SLQLDPAQIY | RVTWFISWSP |
CFSWGCAGEV | RAFLQENTHV | RLRIFAARIY | DYDPLYKEAL | QMLRDAGAQV |
SIMTYDEFKH | CWDTFVDHQG | CPFQPWDGLD | EHSQALSGRL | RAILQNQGN
This product has not yet been referenced specifically in any publications.
"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."
"APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons."
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
"Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."
"APOBEC3A can activate the DNA damage response and cause cell-cycle arrest."
"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
"Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities."
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