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首页  >  酶联免疫试剂盒  >  Human APOBEC3A ELISA Kit
APOBEC3A (基因名), DNA dC->dU-editing enzyme APOBEC-3A (蛋白名), ABC3A_HUMAN.
产品名称:

Human APOBEC3A/ DNA dC->dU-editing enzyme APOBEC-3A ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

A3A, Phorbolin-1

检测方法:
ELISA
特异性:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human APOBEC3A ELISA Kit
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Human APOBEC3A ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with AGO2. Interacts with TRIB3 (via N-terminus).


功能:
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.


亚细胞位置:
Nucleus Cytoplasm


该产品尚未在任何出版物中被引用。

[1].
"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."

[2].
"APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons."

[3].
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."

[4].
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."

[5].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."

[6].
"Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."

[7].
"APOBEC3A can activate the DNA damage response and cause cell-cycle arrest."

[8].
"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."

[9].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."

[10].
"Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities."
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