APOBEC3A (GeneName), DNA dC->dU-editing enzyme APOBEC-3A (ProteinName), ABC3A_HUMAN.
Product Name:
Human APOBEC3A/ DNA dC->dU-editing enzyme APOBEC-3A ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
A3A, Phorbolin-1
Detection Method:
ELISA
Specificity:
Natural and recombinant human DNA dC->dU-editing enzyme APOBEC-3A
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Interacts with AGO2. Interacts with TRIB3 (via N-terminus).
Function:
DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Subcellular Location:
Nucleus
Cytoplasm
Database link
UniGene:
SMR:
STRING:
KEGG:
MIM:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Psoriasis upregulated phorbolin-1 shares structural but not functional similarity to the mRNA-editing protein apobec-1."
[2].
"APOBEC3A is a potent inhibitor of adeno-associated virus and retrotransposons."
[3].
"An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22."
[4].
"APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1."
[5].
"HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies."
[6].
"Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A."
[8].
"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
[9].
"Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1."
[10].
"Structure-function analyses point to a polynucleotide-accommodating groove essential for APOBEC3A restriction activities."
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