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Apbb1ip (GeneName), Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (ProteinName), AB1IP_MOUSE.

Product Name:

Mouse Apbb1ip/ Amyloid beta A4 precursor protein-binding family B member 1-interacting protein ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

APBB1-interacting protein 1, Proline-rich EVH1 ligand 1, PREL-1, Proline-rich protein 48, Prel1

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse Amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Mouse Apbb1ip ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH.

Function:

Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.

Subcellular Location:

Cell membrane Peripheral membrane protein Cell projection Lamellipodium Cell junction Focal adhesion Cytoplasm Cytoskeleton Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.

Database link

UniGene:

Mm.14255

SMR:

Q8R5A3

STRING:

10090.ENSMUSP00000014290

KEGG:

mmu:54519

Pfam:

PF00169

Uniprot:

Q8R5A3

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Sequence length:

670

Sequence:

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670:

EQDFMSDLMK | ALQKKRGNIP |

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion."

(PMID: 15469846)

[2].

"The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells."

(PMID: 14530287)

[3].

"A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network."

(PMID: 22228203)

[4].

"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

(PMID: 20379614)

[5].

"Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease."

(PMID: 17373700)

[6].

"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."

(PMID: 16385451)

[7].

"PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins."