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APBB1IP (GeneName), Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (ProteinName), AB1IP_HUMAN.
Product Name:

Human APBB1IP/ Amyloid beta A4 precursor protein-binding family B member 1-interacting protein ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

APBB1-interacting protein 1, Proline-rich EVH1 ligand 1, PREL-1, Proline-rich protein 73, Rap1-GTP-interacting adapter molecule, RIAM, Retinoic acid-responsive proline-rich protein 1, RARP-1, PREL1, RARP1, RIAM

Detection Method:
ELISA
Specificity:
Natural and recombinant human Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human APBB1IP ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, TLN1, VASP, VCL and ENAH.


Function:
Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.


Subcellular Location:
Cell membrane Peripheral membrane protein Cell projection Lamellipodium Cell junction Focal adhesion Cytoplasm Cytoskeleton Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity).


This product has not yet been referenced specifically in any publications.

[1].
"RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion."

[2].
"The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells."

[3].
"A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network."

[4].
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."

[5].
"Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease."

[6].
"A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease."

[7].
"PREL1 provides a link from Ras signalling to the actin cytoskeleton via Ena/VASP proteins."

[8].
"The DNA sequence and comparative analysis of human chromosome 10."

[9].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."

[10].
"The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled."
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