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首页  >  酶联免疫试剂盒  >  Rat Aatf ELISA Kit
Aatf (基因名), Protein AATF (蛋白名), AATF_RAT.
产品名称:

Rat Aatf/ Protein AATF ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Apoptosis-antagonizing transcription factor

检测方法:
ELISA
特异性:
Natural and recombinant rat Protein AATF
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Aatf ELISA Kit
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产品说明书


通用注释


亚单元:
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130 and SP1 (By similarity). Binds DAPK3/ZIPK and TSG101. May also bind MAPT.


功能:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation.


亚细胞位置:
Nucleus


该产品尚未在任何出版物中被引用。

[1].
"Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb."

[2].
"AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."

[3].
"AATF protects neural cells against oxidative damage induced by amyloid beta-peptide."

[4].
"Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis."

[5].
"Identification of novel transcription factor-like gene from human intestinal cells."

[6].
"Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes."

[7].
"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."

[8].
"Mutation analysis of the AATF gene in breast cancer families."

[9].
"Functional characterization of AATF transcriptome in human leukemic cells."

[10].
"NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death."
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