Aatf (GeneName), Protein AATF (ProteinName), AATF_RAT.
Product Name:
Rat Aatf/ Protein AATF ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Apoptosis-antagonizing transcription factor
Detection Method:
ELISA
Specificity:
Natural and recombinant rat Protein AATF
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
- Feedback Wall (0)
General Annotation
Sub Unit:
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130 and SP1 (By similarity). Binds DAPK3/ZIPK and TSG101. May also bind MAPT.
Function:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation (By similarity). May negatively regulate the pro-apoptotic activity of DAPK3/ZIPK. Can act cooperatively with TSG101 to stimulate AR mediated transcription activation.
Subcellular Location:
Nucleus
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb."
[2].
"AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."
[3].
"AATF protects neural cells against oxidative damage induced by amyloid beta-peptide."
[4].
"Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis."
[5].
"Identification of novel transcription factor-like gene from human intestinal cells."
[6].
"Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes."
[7].
"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."
[10].
"NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death."
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