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AATF (基因名), Protein AATF (蛋白名), AATF_HUMAN.
产品名称:

Human AATF/ Protein AATF ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, HSPC277, CHE1, DED

检测方法:
ELISA
特异性:
Natural and recombinant human Protein AATF
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human AATF ELISA Kit
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Human AATF ELISA Kit
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通用注释


亚单元:
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.


功能:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.


亚细胞位置:
Nucleus Nucleolus


该产品尚未在任何出版物中被引用。
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