AATF (GeneName), Protein AATF (ProteinName), AATF_HUMAN.
Human AATF/ Protein AATF ELISA Kit
Apoptosis-antagonizing transcription factor, Rb-binding protein Che-1, CHE1, DED, HSPC277
Natural and recombinant human Protein AATF
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Binds PAWR, POLR2J, RB1/RB, RBL1/P107, RBL2/P130, and SP1. May also bind MAPT.
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
MAGPQPLALQ | LEQLLNPRPS | EADPEADPEE | ATAARVIDRF | DEGEDGEGDF |
LVVGSIRKLA | SASLLDTDKR | YCGKTTSRKA | WNEDHWEQTL | PGSSDEEISD |
EEGSGDEDSE | GLGLEEYDED | DLGAAEEQEC | GDHRESKKSR | SHSAKTPGFS |
VQSISDFEKF | TKGMDDLGSS | EEEEDEESGM | EEGDDAEDSQ | GESEEDRAGD |
RNSEDDGVVM | TFSSVKVSEE | VEKGRAVKNQ | IALWDQLLEG | RIKLQKALLT |
TNQLPQPDVF | PLFKDKGGPE | FSSALKNSHK | ALKALLRSLV | GLQEELLFQY |
PDTRYLVDGT | KPNAGSEEIS | SEDDELVEEK | KQQRRRVPAK | RKLEMEDYPS |
FMAKRFADFT | VYRNRTLQKW | HDKTKLASGK | LGKGFGAFER | SILTQIDHIL |
MDKERLLRRT | QTKRSVYRVL | GKPEPAAQPV | PESLPGEPEI | LPQAPANAHL |
KDLDEEIFDD | DDFYHQLLRE | LIERKTSSLD | PNDQVAMGRQ | WLAIQKLRSK |
IHKKVDRKAS | KGRKLRFHVL | SKLLSFMAPI | DHTTMNDDAR | TELYRSLFGQ |
This product has not yet been referenced specifically in any publications.
"Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb."
"AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4."
"AATF protects neural cells against oxidative damage induced by amyloid beta-peptide."
"Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis."
"Identification of novel transcription factor-like gene from human intestinal cells."
"Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes."
"Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging."
"Mutation analysis of the AATF gene in breast cancer families."
"Functional characterization of AATF transcriptome in human leukemic cells."
"NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death."
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