GOT1 (GeneName), Aspartate aminotransferase, cytoplasmic (ProteinName), AATC_HORSE.
Horse GOT1/ Aspartate aminotransferase, cytoplasmic ELISA Kit
cAspAT, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A
Natural and recombinant horse Aspartate aminotransferase, cytoplasmic
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
MTSPSIFVEV | PQAQPVLVFK | LTADFREDPD | PRKVNLGVGA | YRTDDCQPWV |
LPVVRKVEQK | IANNSSLNHE | YLPILGLAEF | RSCASRLALG | DDSPALQEKR |
VGGVQSLGGT | GALRIGAEFL | SRWYNGTNNK | NTPVYVSSPT | WENHNGVFSG |
AGFKDIRSYH | YWDATKRGLD | LQGFLNDLEN | APEFSIFVLH | ACAHNPTGTD |
PTPEQWKQIA | SVMKRRFLFP | FFDSAYQGFA | SGNLDRDAWA | VRYFVSEGFE |
LFCAQSFSKN | FGLYNERVGN | LTVVAKEPDS | ILRVLSQMQK | IVRITWSNPP |
AQGARIVAFT | LSDPGLFKEW | TGNVKTMADR | ILSMRSELRA | RLEALKTPGT |
WNHITEQIGM | FSFTGLNPKQ | VEYLVNQKHI | YLLPSGRINM | CGLTTKNLDY |
VATSIHEAVT | KFQ
This product has not yet been referenced specifically in any publications.
"Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection."
"Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels."
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
"The DNA sequence and comparative analysis of human chromosome 10."
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
"Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene."
"The amino acid sequence of cytosolic aspartate aminotransferase from human liver."
"Neither ischemic parenchymal volume nor severe grade complication correlate transient high transaminase elevation after liver resection."
"Architecture of the human interactome defines protein communities and disease networks."
"HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma."
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