GOT1 (GeneName), Aspartate aminotransferase, cytoplasmic (ProteinName), AATC_CHICK.
Product Name:
Chicken GOT1/ Aspartate aminotransferase, cytoplasmic ELISA Kit
Cat.#:
E1214c
Brand:
EIAab®
Regulatory Status:
Alternative:
cAspAT, Cysteine aminotransferase, cytoplasmic, Cysteine transaminase, cytoplasmic, cCAT, Glutamate oxaloacetate transaminase 1, Transaminase A
Detection Method:
ELISA
Specificity:
Natural and recombinant chicken Aspartate aminotransferase, cytoplasmic
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
Cell Biology
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Homodimer.
Function:
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Subcellular Location:
Cytoplasm
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Properties of human liver cytosolic aspartate aminotransferase mRNAs generated by alternative polyadenylation site selection."
[2].
"Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels."
[3].
"Human variation in alcohol response is influenced by variation in neuronal signaling genes."
[5].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[6].
"Genetic homogeneity, high-resolution mapping, and mutation analysis of the urofacial (Ochoa) syndrome and exclusion of the glutamate oxaloacetate transaminase gene (GOT1) in the critical region as the disease gene."
[7].
"The amino acid sequence of cytosolic aspartate aminotransferase from human liver."
[8].
"Neither ischemic parenchymal volume nor severe grade complication correlate transient high transaminase elevation after liver resection."
[9].
"Architecture of the human interactome defines protein communities and disease networks."
[10].
"HIF-2α regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma."
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