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首页  >  酶联免疫试剂盒  >  Pig PRKAG3 ELISA Kit
PRKAG3 (基因名), 5'-AMP-activated protein kinase subunit gamma-3 (蛋白名), AAKG3_PIG.
产品名称:

Pig PRKAG3/ 5'-AMP-activated protein kinase subunit gamma-3 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

AMPK gamma3

检测方法:
ELISA
特异性:
Natural and recombinant pig 5'-AMP-activated protein kinase subunit gamma-3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cardiovascular
Pig PRKAG3 ELISA Kit
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Pig PRKAG3 ELISA Kit
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产品说明书


通用注释


亚单元:
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.


功能:
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.


亚细胞位置:
N/A


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