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Prkag1 (GeneName), 5'-AMP-activated protein kinase subunit gamma-1 (ProteinName), AAKG1_MOUSE.

Product Name:

Mouse Prkag1/ 5'-AMP-activated protein kinase subunit gamma-1 ELISA Kit

Cat.#:

E10187m

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

AMPK gamma1, Prkaac

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse 5'-AMP-activated protein kinase subunit gamma-1

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

Cardiovascular

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Mouse Prkag1 ELISA Kit

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Product Datasheets

Data
Citations
Sequence / 3D
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General Annotation

Sub Unit:

AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.

Function:

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

Subcellular Location:

N/A

Database link

UniGene:

Mm.6670

SMR:

O54950

STRING:

10090.ENSMUSP00000132499

KEGG:

mmu:19082

Pfam: