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PRKAB1 (GeneName), 5'-AMP-activated protein kinase subunit beta-1 (ProteinName), AAKB1_PIG.
Product Name:

Pig PRKAB1/ 5'-AMP-activated protein kinase subunit beta-1 ELISA Kit

Cat.#:

E1671p

Brand:
EIAab®
Regulatory Status:
Alternative:

AMPK subunit beta-1, 5'-AMP-activated protein kinase 40 kDa subunit

Detection Method:
ELISA
Assay Type:
Sandwich
Specificity:
Natural and recombinant pig 5'-AMP-activated protein kinase subunit beta-1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
Cardiovascular
Pig PRKAB1 ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of 5'-AMP-activated protein kinase subunit beta-1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

82-91%

101-111%

108-118%

104-114%

EDTA plasma(n=5)

108-117%

108-118%

109-120%

81-93%

heparin plasma(n=5)

98-108%

 

94-104%

115-125%

110-122%

 

General Annotation


Sub Unit:
AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.


Function:
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).


Subcellular Location:
N/A


This product has not yet been referenced specifically in any publications.
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