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首页  >  酶联免疫试剂盒  >  Rat Aak1 ELISA Kit
Aak1 (基因名), AP2-associated protein kinase 1 (蛋白名), AAK1_RAT.
产品名称:

Rat Aak1/ AP2-associated protein kinase 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Adaptor-associated kinase 1

检测方法:
ELISA
特异性:
Natural and recombinant rat AP2-associated protein kinase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Aak1 ELISA Kit
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Rat Aak1 ELISA Kit
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产品说明书


通用注释


亚单元:
Interacts with alpha-adaptin, AP-2, clathrin, NUMB and EPS15. Interacts with membrane-bound activated NOTCH1 but not with the inactive full-length form of NOTCH1. Preferentially interacts with monoubiquitinated activated NOTCH1 compared to the non-ubiquitinated form.


功能:
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.


亚细胞位置:
Cell membrane Peripheral membrane protein Membrane Clathrin-coated pit Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells.


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