AAK1 (GeneName), AP2-associated protein kinase 1 (ProteinName), AAK1_HUMAN.
Human AAK1/ AP2-associated protein kinase 1 ELISA Kit
Adaptor-associated kinase 1, KIAA1048
Natural and recombinant human AP2-associated protein kinase 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with alpha-adaptin, AP-2, clathrin, NUMB and EPS15 isoform 2. Interacts with membrane-bound activated NOTCH1 but not with the inactive full-length form of NOTCH1. Preferentially interacts with monoubiquitinated activated NOTCH1 compared to the non-ubiquitinated form.
Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Cell membrane Peripheral membrane protein Membrane Clathrin-coated pit Active when found in clathrin-coated pits at the plasma membrane. In neuronal cells, enriched at presynaptic terminals. In non-neuronal cells, enriched at leading edge of migrating cells (By similarity).
MKKFFDSRRE | QGGSGLGSGS | SGGGGSTSGL | GSGYIGRVFG | IGRQQVTVDE |
VLAEGGFAIV | FLVRTSNGMK | CALKRMFVNN | EHDLQVCKRE | IQIMRDLSGH |
KNIVGYIDSS | INNVSSGDVW | EVLILMDFCR | GGQVVNLMNQ | RLQTGFTENE |
VLQIFCDTCE | AVARLHQCKT | PIIHRDLKVE | NILLHDRGHY | VLCDFGSATN |
KFQNPQTEGV | NAVEDEIKKY | TTLSYRAPEM | VNLYSGKIIT | TKADIWALGC |
LLYKLCYFTL | PFGESQVAIC | DGNFTIPDNS | RYSQDMHCLI | RYMLEPDPDK |
RPDIYQVSYF | SFKLLKKECP | IPNVQNSPIP | AKLPEPVKAS | EAAAKKTQPK |
ARLTDPIPTT | ETSIAPRQRP | KAGQTQPNPG | ILPIQPALTP | RKRATVQPPP |
QAAGSSNQPG | LLASVPQPKP | QAPPSQPLPQ | TQAKQPQAPP | TPQQTPSTQA |
QGLPAQAQAT | PQHQQQLFLK | QQQQQQQPPP | AQQQPAGTFY | QQQQAQTQQF |
QAVHPATQKP | AIAQFPVVSQ | GGSQQQLMQN | FYQQQQQQQQ | QQQQQQLATA |
LHQQQLMTQQ | AALQQKPTMA | AGQQPQPQPA | AAPQPAPAQE | PAIQAPVRQQ |
PKVQTTPPPA | VQGQKVGSLT | PPSSPKTQRA | GHRRILSDVT | HSAVFGVPAS |
KSTQLLQAAA | AEASLNKSKS | ATTTPSGSPR | TSQQNVYNPS | EGSTWNPFDD |
DNFSKLTAEE | LLNKDFAKLG | EGKHPEKLGG | SAESLIPGFQ | STQGDAFATT |
SFSAGTAEKR | KGGQTVDSGL | PLLSVSDPFI | PLQVPDAPEK | LIEGLKSPDT |
SLLLPDLLPM | TDPFGSTSDA | VIEKADVAVE | SLIPGLEPPV | PQRLPSQTES |
VTSNRTDSLT | GEDSLLDCSL | LSNPTTDLLE | EFAPTAISAP | VHKAAEDSNL |
ISGFDVPEGS | DKVAEDEFDP | IPVLITKNPQ | GGHSRNSSGS | SESSLPNLAR |
SLLLVDQLID | L
This product has not yet been referenced specifically in any publications.
"AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis."
"Differential requirements for AP-2 in clathrin-mediated endocytosis."
"The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Genomewide association study for onset age in Parkinson disease."
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