AADAT (GeneName), Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (ProteinName), AADAT_HUMAN.
Product Name:
Human AADAT/ Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial ELISA Kit
Cat.#:
E12537h
Brand:
EIAab®
Regulatory Status:
Alternative:
KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, KAT2
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.312-20ng/ml
Sensitivity:
0.1ng/ml
Specificity:
Natural and recombinant human Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:

Research Area:
Cell Biology
- Data
- Citations
- Publication
- Sequence / 3D
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Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤5.8%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤8.6%
Recovery
Recovery was determined by spiking various levels of Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial into serum and plasma.
Sample Type |
Average(%) |
Recovery Range(%) |
Serum |
89 |
83-95 |
Plasma |
91 |
85-97 |
Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial and their serial dilutions.
The results were demonstrated by the percentage of calculated concentration to the expected.
Sample |
1:2 |
1:4 |
1:8 |
1:16 |
serum(n=5) |
97-108% |
108-118% |
84-95% |
83-93% |
EDTA plasma(n=5) |
90-100% |
109-119% |
95-107% |
104-114% |
heparin plasma(n=5) |
81-92%
|
103-115% |
86-96% |
96-106% |
General Annotation
Sub Unit:
Homodimer.
Function:
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
Subcellular Location:
Mitochondrion
This product has not yet been referenced specifically in any publications.
[2].
"Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia."
[3].
"Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II."
[4].
"Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)."
[5].
"Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease."
[6].
"Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression."
[8].
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[9].
"2-Aminoadipate-2-oxoglutarate aminotransferase isoenzymes in human liver: a plausible physiological role in lysine and tryptophan metabolism."
[10].
"Architecture of the human interactome defines protein communities and disease networks."
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