AADAC (基因名), Arylacetamide deacetylase (蛋白名), AAAD_HUMAN.
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.
Endoplasmic reticulum membrane Single-pass type II membrane protein Microsome membrane Single-pass type II membrane protein
MGRKSLYLLI | VGILIAYYIY | TPLPDNVEEP | WRMMWINAHL | KTIQNLATFV |
ELLGLHHFMD | SFKVVGSFDE | VPPTSDENVT | VTETKFNNIL | VRVYVPKRKS |
EALRRGLFYI | HGGGWCVGSA | ALSGYDLLSR | WTADRLDAVV | VSTNYRLAPK |
YHFPIQFEDV | YNALRWFLRK | KVLAKYGVNP | ERIGISGDSA | GGNLAAAVTQ |
QLLDDPDVKI | KLKIQSLIYP | ALQPLDVDLP | SYQENSNFLF | LSKSLMVRFW |
SEYFTTDRSL | EKAMLSRQHV | PVESSHLFKF | VNWSSLLPER | FIKGHVYNNP |
NYGSSELAKK | YPGFLDVRAA | PLLADDNKLR | GLPLTYVITC | QYDLLRDDGL |
MYVTRLRNTG | VQVTHNHVED | GFHGAFSFLG | LKISHRLINQ | YIEWLKENL
"Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase."
"Human arylacetamide deacetylase is a principal enzyme in flutamide hydrolysis."
"Purification and characterization of a human liver arylacetamide deacetylase."
"N-Glycosylation during translation is essential for human arylacetamide deacetylase enzyme activity."
"Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production."
"A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity."
"Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
"Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency."
"Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects."
"Human carboxylesterases and their role in xenobiotic and endobiotic metabolism."
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