ATXN7L3B (基因名), Ataxin-7-like protein 3B (蛋白名), A7L3B_HUMAN.
Interacts strongly with ENY2. Interacts weakly with USP22.
By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.
"Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module."
"Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7."
"Deletion of chromosome 12q21 affecting KCNC2 and ATXN7L3B in a family with neurodevelopmental delay and ataxia."
"RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination."
"Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family."
"Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
"Defining the human deubiquitinating enzyme interaction landscape."
"Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study."
"Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study."
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