A4galt (GeneName), Lactosylceramide 4-alpha-galactosyltransferase (ProteinName), A4GAT_RAT.
Rat A4galt/ Lactosylceramide 4-alpha-galactosyltransferase ELISA Kit
Alpha-1, 4-N-acetylglucosaminyltransferase, Alpha-1, 4-galactosyltransferase, Alpha4Gal-T1, Globotriaosylceramide synthase, Gb3 synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
Natural and recombinant rat Lactosylceramide 4-alpha-galactosyltransferase
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
Golgi apparatus membrane Single-pass type II membrane protein
MGISRSDLEE | TMSKPPDCLP | RMLRGTPRQR | VFTLFIISFK | FTFLVSILIY |
WHTVGAPKDQ | RRQYSLPVDF | PCPQLAFPRV | SAPGNIFFLE | TSDRTNPSFL |
FMCSVESAAR | AHPESQVVVL | MKGLPRDTTA | WPRNLGISLL | SCFPNVQIRP |
LDLQELFEDT | PLAAWYLEAQ | HRWEPYLLPV | LSDASRIALL | WKFGGIYLDT |
DFIVLKNLRN | LTNMLGIQSR | YVLNGAFLAF | ERKHEFLALC | IRDFVAHYNG |
WIWGHQGPQL | LTRVFKKWCS | IHSLKESRAC | RGVTALPPEA | FYPIPWQNWK |
KYFEDVSPEE | LAQLLNATYA | VHVWNKKSQG | THLEATSRAL | LAQLHARYCP |
This product has not yet been referenced specifically in any publications.
"Three-base deletion and one-base insertion of the alpha(1,4)galactosyltransferase gene responsible for the P phenotype."
"Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals."
"Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype."
"Molecular basis for the p phenotype. Identification of distinct and multiple mutations in the alpha 1,4-galactosyltransferase gene in Swedish and Japanese individuals."
"A single point mutation in the gene encoding Gb3/CD77 synthase causes a rare inherited polyagglutination syndrome."
"Identification of a novel A4GALT exon reveals the genetic basis of the P1/P2 histo-blood groups."
"Globotriaosylceramide (Gb3) content in HeLa cells is correlated to Shiga toxin-induced cytotoxicity and Gb3 synthase expression."
"Expression of a novel missense mutation found in the A4GALT gene of Amish individuals with the p phenotype."
"Two previously proposed P1/P2-differentiating and nine novel polymorphisms at the A4GALT (Pk) locus do not correlate with the presence of the P1 blood group antigen."
"Genetic heterogeneity at the glycosyltransferase loci underlying the GLOB blood group system and collection."
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