A3galt2 (GeneName), Alpha-1,3-galactosyltransferase 2 (ProteinName), A3LT2_RAT.
Rat A3galt2/ Alpha-1,3-galactosyltransferase 2 ELISA Kit
Isoglobotriaosylceramide synthase, iGb3 synthase
Natural and recombinant rat Alpha-1,3-galactosyltransferase 2
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids.
Golgi apparatus Golgi stack membrane Single-pass type II membrane protein Also found in numerous large vesicles throughout the cytoplasm of the soma.
MALEGLRAKK | RLLWRLFLSA | FGLLGLYHYW | FKIFRLFEVF | IPMGICPMAI |
MPLLKDNFTG | VLRHWARPEV | LTCTSWGAPI | IWDETFDPHV | AEREARRQNL |
TIGLTVFAVG | RYLEKYLEHF | LVSAEQYFMV | GQNVVYYVFT | DRPEAVPHVA |
LGQGRLLRVK | PVRREKRWQD | VSMARMLTLH | EALGGQLGRE | ADYVFCLDVD |
QYFSGNFGPE | VLADLVAQLH | AWHFRWPRWM | LPYERDKRSA | AALSLSEGDF |
YYHAAVFGGS | VAALLKLTAH | CATGQQLDRE | HGIEARWHDE | SHLNKFFWLS |
KPTKLLSPEF | CWAEEIGWRP | EIHHPRLIWA | PKEYALVRT
This product has not yet been referenced specifically in any publications.
"Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation."
"Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology."
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
"Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry."
"Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity."
"Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies."
"The DNA sequence and biological annotation of human chromosome 1."
"Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids."
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