A3galt2 (GeneName), Alpha-1,3-galactosyltransferase 2 (ProteinName), A3LT2_RAT.
Product Name:
Rat A3galt2/ Alpha-1,3-galactosyltransferase 2 ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Isoglobotriaosylceramide synthase, iGb3 synthase
Detection Method:
ELISA
Specificity:
Natural and recombinant rat Alpha-1,3-galactosyltransferase 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
N/A
Function:
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids.
Subcellular Location:
Golgi apparatus
Golgi stack membrane
Single-pass type II membrane protein
Also found in numerous large vesicles throughout the cytoplasm of the soma.
Database link
UniGene:
SMR:
STRING:
KEGG:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation."
[2].
"Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology."
[3].
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
[4].
"Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry."
[5].
"Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity."
[6].
"Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies."
[8].
"Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids."
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