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A3galt2 (GeneName), Alpha-1,3-galactosyltransferase 2 (ProteinName), A3LT2_RAT.
Product Name:

Rat A3galt2/ Alpha-1,3-galactosyltransferase 2 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Isoglobotriaosylceramide synthase, iGb3 synthase

Detection Method:
ELISA
Specificity:
Natural and recombinant rat Alpha-1,3-galactosyltransferase 2
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Rat A3galt2 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
N/A


Function:
Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo-series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and is solely responsible for initiating the synthesis of isoglobo-series glycosphingolipids.


Subcellular Location:
Golgi apparatus Golgi stack membrane Single-pass type II membrane protein Also found in numerous large vesicles throughout the cytoplasm of the soma.


This product has not yet been referenced specifically in any publications.

[1].
"Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation."

[2].
"Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology."

[3].
"Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."

[4].
"Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry."

[5].
"Structural basis of UDP-galactose binding by alpha-1,3-galactosyltransferase (alpha3GT): role of negative charge on aspartic acid 316 in structure and activity."

[6].
"Carbohydrate residues downstream of the terminal Galalpha(1,3)Gal epitope modulate the specificity of xenoreactive antibodies."

[7].
"The DNA sequence and biological annotation of human chromosome 1."

[8].
"Expression cloning of a new member of the ABO blood group glycosyltransferases, iGb3 synthase, that directs the synthesis of isoglobo-glycosphingolipids."
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