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A2m (GeneName), Alpha-2-macroglobulin (ProteinName), A2M_MOUSE.

Product Name:

Mouse A2m/ Alpha-2-macroglobulin ELISA Kit

Cat.#:

E1017m

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

Alpha-2-M, Pregnancy zone protein, Pzp

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

0.156-10ng/mL

Sensitivity:

0.089ng/mL

Specificity:

Natural and recombinant mouse Alpha-2-macroglobulin

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

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Mouse A2m ELISA Kit

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Product Datasheets

Datasheet:

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

N/A

Function:

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Subcellular Location:

Secreted

Database link

Uniprot:

Q61838

Related Product

Sequence length:

1495

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1495:

AVEQDIPVKN | LKPAPIKVYD | YYETDEFTVE | EYSAPFSDGS | EQGNA

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Human alpha2-macroglobulin: genotype-phenotype relation."

(PMID: 14637088)

[2].

"Alpha-2 macroglobulin is genetically associated with Alzheimer disease."

(PMID: 9697696)

[3].

"Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site."

(PMID: 1370808)

[4].

"Structure of the human alpha-2 macroglobulin gene and its promotor."

(PMID: 1374237)

[5].

"Human alpha 2-macroglobulin gene is located on chromosome 12."

(PMID: 2408344)

[6].

"Association between haplotype -88G/25G in A2M with Alzheimer's disease."

(PMID: 20493925)

[7].

"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

(PMID: 20587546)

[8].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[9].

"Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease."

(PMID: 20637261)

[10].

"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."

(PMID: 20800603)

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