A2mp (GeneName), Alpha-2-macroglobulin-P (ProteinName), A2MP_MOUSE.
Product Name:
Mouse A2mp/ Alpha-2-macroglobulin-P ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
Alpha-2-macroglobulin, A2m
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Alpha-2-macroglobulin-P
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Sequence / 3D
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General Annotation
Sub Unit:
Homotetramer; disulfide-linked.
Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subcellular Location:
Secreted
Valid Sequence:
This product has not yet been referenced specifically in any publications.
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