A2ML1 (GeneName), Alpha-2-macroglobulin-like protein 1 (ProteinName), A2ML1_HUMAN.
Human A2ML1/ Alpha-2-macroglobulin-like protein 1 ELISA Kit
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9, CPAMD9
Natural and recombinant human Alpha-2-macroglobulin-like protein 1
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases.
MWAQLLLGML | ALSPAIAEEL | PNYLVTLPAR | LNFPSVQKVC | LDLSPGYSDV |
KFTVTLETKD | KTQKLLEYSG | LKKRHLHCIS | FLVPPPAGGT | EEVATIRVSG |
VGNNISFEEK | KKVLIQRQGN | GTFVQTDKPL | YTPGQQVYFR | IVTMDSNFVP |
VNDKYSMVEL | QDPNSNRIAQ | WLEVVPEQGI | VDLSFQLAPE | AMLGTYTVAV |
AEGKTFGTFS | VEEYVLPKFK | VEVVEPKELS | TVQESFLVKI | CCRYTYGKPM |
LGAVQVSVCQ | KANTYWYREV | EREQLPDKCR | NLSGQTDKTG | CFSAPVDMAT |
FDLIGYAYSH | QINIVATVVE | EGTGVEANAT | QNIYISPQMG | SMTFEDTSNF |
YHPNFPFSGK | IRVRGHDDSF | LKNHLVFLVI | YGTNGTFNQT | LVTDNNGLAP |
FTLETSGWNG | TDVSLEGKFQ | MEDLVYNPEQ | VPRYYQNAYL | HLRPFYSTTR |
SFLGIHRLNG | PLKCGQPQEV | LVDYYIDPAD | ASPDQEISFS | YYLIGKGSLV |
MEGQKHLNSK | KKGLKASFSL | SLTFTSRLAP | DPSLVIYAIF | PSGGVVADKI |
QFSVEMCFDN | QVSLGFSPSQ | QLPGAEVELQ | LQAAPGSLCA | LRAVDESVLL |
LRPDRELSNR | SVYGMFPFWY | GHYPYQVAEY | DQCPVSGPWD | FPQPLIDPMP |
QGHSSQRSII | WRPSFSEGTD | LFSFFRDVGL | KILSNAKIKK | PVDCSHRSPE |
YSTAMGAGGG | HPEAFESSTP | LHQAEDSQVR | QYFPETWLWD | LFPIGNSGKE |
AVHVTVPDAI | TEWKAMSFCT | SQSRGFGLSP | TVGLTAFKPF | FVDLTLPYSV |
VRGESFRLTA | TIFNYLKDCI | RVQTDLAKSH | EYQLESWADS | QTSSCLCADD |
AKTHHWNITA | VKLGHINFTI | STKILDSNEP | CGGQKGFVPQ | KGRSDTLIKP |
VLVKPEGVLV | EKTHSSLLCP | KGKVASESVS | LELPVDIVPD | STKAYVTVLG |
DIMGTALQNL | DGLVQMPSGC | GEQNMVLFAP | IIYVLQYLEK | AGLLTEEIRS |
RAVGFLEIGY | QKELMYKHSN | GSYSAFGERD | GNGNTWLTAF | VTKCFGQAQK |
FIFIDPKNIQ | DALKWMAGNQ | LPSGCYANVG | NLLHTAMKGG | VDDEVSLTAY |
VTAALLEMGK | DVDDPMVSQG | LRCLKNSATS | TTNLYTQALL | AYIFSLAGEM |
DIRNILLKQL | DQQAIISGES | IYWSQKPTPS | SNASPWSEPA | AVDVELTAYA |
LLAQLTKPSL | TQKEIAKATS | IVAWLAKQHN | AYGGFSSTQD | TVVALQALAK |
YATTAYMPSE | EINLVVKSTE | NFQRTFNIQS | VNRLVFQQDT | LPNVPGMYTL |
EASGQGCVYV | QTVLRYNILP | PTNMKTFSLS | VEIGKARCEQ | PTSPRSLTLT |
IHTSYVGSRS | SSNMAIVEVK | MLSGFSPMEG | TNQLLLQQPL | VKKVEFGTDT |
LNIYLDELIK | NTQTYTFTIS | QSVLVTNLKP | ATIKVYDYYL | PDEQATIQYS |
This product has not yet been referenced specifically in any publications.
"A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis."
"Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"Architecture of the human interactome defines protein communities and disease networks."
"Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline."
"Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population."
"Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene."
"Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome."
"Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes."
"External ear anomalies and hearing impairment in Noonan Syndrome."
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