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A2m (GeneName), Alpha-2-macroglobulin-P (ProteinName), A2MG_MOUSE.
Product Name:

Mouse A2m/ Alpha-2-macroglobulin-P ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

Alpha-2-macroglobulin, A2mp

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse Alpha-2-macroglobulin-P
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse A2m ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Homotetramer; disulfide-linked.


Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.


Subcellular Location:
Secreted


This product has not yet been referenced specifically in any publications.

[1].
"Human alpha2-macroglobulin: genotype-phenotype relation."

[2].
"Alpha-2 macroglobulin is genetically associated with Alzheimer disease."

[3].
"Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site."

[4].
"Structure of the human alpha-2 macroglobulin gene and its promotor."

[5].
"Human alpha 2-macroglobulin gene is located on chromosome 12."

[6].
"Association between haplotype -88G/25G in A2M with Alzheimer's disease."

[7].
"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease."

[10].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
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