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首页  >  酶联免疫试剂盒  >  Human A2M ELISA Kit
A2M (基因名), Alpha-2-macroglobulin (蛋白名), A2MG_HUMAN.
产品名称:

Human A2M/ Alpha-2-macroglobulin ELISA Kit
α-2巨球蛋白

货号:

E1017h

商标:
EIAab®
监管等级:
别名:

Alpha-2-M, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, FWP007

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
7.8-500ng/mL
灵敏度:
3.9ng/mL
特异性:
Natural and recombinant human Alpha-2-macroglobulin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human A2M ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤4.5%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤8.6%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

94

88-100

Plasma

96

90-102

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

106-115%

102-112%

104-112%

109-120%

EDTA plasma(n=5)

93-103%

107-117%

100-110%

106-115%

heparin plasma(n=5)

91-100%

 

93-104%

103-115%

112-120%

 

通用注释


亚单元:
Homotetramer; disulfide-linked.


功能:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.


亚细胞位置:
Secreted


该产品尚未在任何出版物中被引用。

[1].
"Human alpha2-macroglobulin: genotype-phenotype relation."

[2].
"Alpha-2 macroglobulin is genetically associated with Alzheimer disease."

[3].
"Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site."

[4].
"Structure of the human alpha-2 macroglobulin gene and its promotor."

[5].
"Human alpha 2-macroglobulin gene is located on chromosome 12."

[6].
"Association between haplotype -88G/25G in A2M with Alzheimer's disease."

[7].
"Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection."

[8].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[9].
"Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease."

[10].
"Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study."
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