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Home  >  ELISA Kit  >  Human SERPINF2 ELISA Kit
SERPINF2 (GeneName), Alpha-2-antiplasmin (ProteinName), A2AP_HUMAN.
Product Name:

Human SERPINF2/ Alpha-2-antiplasmin ELISA Kit

Cat.#:

E0160h

Brand:
EIAab®
Regulatory Status:
Alternative:

Alpha-2-AP, Alpha-2-plasmin inhibitor, Alpha-2-PI, Serpin F2, AAP, PLI

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.9375-60pg/mL
Sensitivity:
0.215pg/mL
Specificity:
Natural and recombinant human Alpha-2-antiplasmin
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
-
Human SERPINF2 ELISA Kit
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Human SERPINF2 ELISA Kit
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Product Datasheets
Datasheet: Down Datasheet
Instruction: Down Instruction
MSDS: MSDS


Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.5%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤8.1%

Recovery
Recovery was determined by spiking various levels of Alpha-2-antiplasmin into serum and plasma.

Sample Type

Average(%)

Recovery Range(%)

Serum

98

92-104

Plasma

100

94-106

 

 

 

 

Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Alpha-2-antiplasmin and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

91-102%

106-115%

101-111%

116-126%

EDTA plasma(n=5)

96-106%

111-120%

104-114%

104-113%

heparin plasma(n=5)

103-113%

 

110-120%

96-105%

103-114%

 

General Annotation


Sub Unit:
Forms protease inhibiting heterodimer with TMPRSS7.


Function:
Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.


Subcellular Location:
Secreted



[1].
"A novel missense mutation in the human plasmin inhibitor (alpha2-antiplasmin) gene associated with a bleeding tendency."

[2].
"Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties."

[3].
"Bovine alpha 2-antiplasmin. N-terminal and reactive site sequence."

[4].
"Update of the human and mouse SERPIN gene superfamily."

[5].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

[6].
"Association studies between the plasmin genes and late-onset Alzheimer's disease."

[7].
"Induction of alpha2-antiplasmin inhibits E-cadherin processing mediated by the plasminogen activator/plasmin system, leading to suppression of progression of oral squamous cell carcinoma via upregulation of cell-cell adhesion."

[8].
"The effect of a single nucleotide polymorphism on human alpha 2-antiplasmin activity."

[9].
"Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate."

[10].
"Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity."
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