A1cf (基因名), APOBEC1 complementation factor (蛋白名), A1CF_RAT.
Rat A1cf/ APOBEC1 complementation factor ELISA Kit
APOBEC1-stimulating protein, Acf, Asp
Natural and recombinant rat APOBEC1 complementation factor
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Part of the apolipoprotein B mRNA editing complex with APOBEC1. Found in a complex with APOBEC1 and CELF2/CUGBP2. Interacts APOBEC1. Interacts with TNPO2; TNPO2 may be responsible for transport of A1CF into the nucleus. Interacts with SYNCRIP. Interacts with CELF2/CUGBP2.
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay.
Nucleus Endoplasmic reticulum Cytoplasm Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum. Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.
MESNHKSGDG | LSGTQKEAAL | RALVQRTGYS | LVQENGQRKY | GGPPPGWDTT |
PPERGCEIFI | GKLPRDLFED | ELIPLCEKIG | KIYEMRMMMD | FNGNNRGYAF |
VTFSNKQEAK | NAIKQLNNYE | IRNGRLLGVC | ASVDNCRLFV | GGIPKTKKRE |
EILSEMKKVT | EGVVDVIVYP | SAADKTKNRG | FAFVEYESHR | AAAMARRRLL |
PGRIQLWGHP | IAVDWAEPEV | EVDEDTMSSV | KILYVRNLML | STSEEMIEKE |
FNSIKPGAVE | RVKKIRDYAF | VHFSNREDAV | EAMKALNGKV | LDGSPIEVTL |
AKPVDKDSYV | RYTRGTGGRN | TMLQEYTYPL | SHVYDPTTTY | LGAPVFYTPQ |
AYAAIPSLHF | PATKGHLSNR | ALIRTPSVRE | IYMNVPVGAA | GVRGLGGRGY |
LAYTGLGRGY | QVKGDKRQDK | LYDLLPGMEL | TPMNTISLKP | QGVKLAPQIL |
EEICQKNNWG | QPVYQLHSAI | GQDQRQLFLY | KVTIPALASQ | NPAIHPFTPP |
KLSAYVDEAK | RYAAEHTLQT | LGIPTEGGDA | GTTAPTATSA | TVFPGYAVPS |
ATAPVSTAQL | KQAVTLGQDL | AAYTTYEVYP | TFAVTTRGDG | YGTF
"The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay."
"A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling."
"Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing."
"Identification of domains in apobec-1 complementation factor required for RNA binding and apolipoprotein-B mRNA editing."
"Isolation, characterization and developmental regulation of the human apobec-1 complementation factor (ACF) gene."
"Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA."
"Targeted deletion of the murine apobec-1 complementation factor (acf) gene results in embryonic lethality."
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
"The DNA sequence and comparative analysis of human chromosome 10."
"Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing."
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