ORM1 (GeneName), Alpha-1-acid glycoprotein 1 (ProteinName), A1AG1_HUMAN.
Product Name:
Human ORM1/ Alpha-1-acid glycoprotein 1 ELISA Kit
Cat.#:
E0816h
Brand:
EIAab®
Regulatory Status:
Alternative:
AGP 1, Orosomucoid-1, OMD 1, AGP1
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.78-50ng/mL
Sensitivity:
0.22ng/mL
Specificity:
Natural and recombinant human Alpha-1-acid glycoprotein 1
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Research Area:
Immunology
- Data
- Citations ( 1 )
- Publication
- Sequence / 3D
- Feedback Wall (0)
Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤4.9%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤7.9%
Recovery
Recovery was determined by spiking various levels of Alpha-1-acid glycoprotein 1 into serum and plasma.
|
Sample Type |
Average(%) |
Recovery Range(%) |
|
Serum |
98 |
92-104 |
|
Plasma |
100 |
94-106 |
Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of Alpha-1-acid glycoprotein 1 and their serial dilutions.
The results were demonstrated by the percentage of calculated concentration to the expected.
|
Sample |
1：2 |
1:4 |
1:8 |
1:16 |
|
serum(n=5) |
101-111% |
103-112% |
106-116% |
97-105% |
|
EDTA plasma(n=5) |
83-93% |
94-103% |
81-92% |
85-95% |
|
heparin plasma(n=5) |
87-96%
|
111-120% |
97-105% |
103-113% |
General Annotation
Sub Unit:
N/A
Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Subcellular Location:
Secreted
Database link
Valid Sequence:
[1].
J Ma, X Luo, Q Wu, et al.
[1].
"Orosomucoid influences the response to antidepressants in major depressive disorder."
[2].
"Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S."
[3].
"Genetic factors (VKORC1, CYP2C9, EPHX1, and CYP4F2) are predictor variables for warfarin response in very elderly, frail inpatients."
[4].
"The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia."
[5].
"Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry."
[6].
"Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia."
[8].
"Genetic factors contribute to patient-specific warfarin dose for Han Chinese."
[9].
"Population pharmacokinetics and pharmacogenetics of imatinib in children and adults."
[10].
"The 1.8-A crystal structure of alpha1-acid glycoprotein (Orosomucoid) solved by UV RIP reveals the broad drug-binding activity of this human plasma lipocalin."
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