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首页  >  酶联免疫试剂盒  >  Human NUDT1 ELISA Kit
NUDT1 (基因名), 7,8-dihydro-8-oxoguanine triphosphatase (蛋白名), 8ODP_HUMAN.
产品名称:

Human NUDT1/ 7,8-dihydro-8-oxoguanine triphosphatase ELISA Kit
7,8-二氢-8氧桥鸟嘌呤三磷酸

货号:

E3104h

商标:
EIAab®
监管等级:
别名:

2-hydroxy-dATP diphosphatase, 8-oxo-dGTPase, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, MTH1

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.78-50ng/mL
灵敏度:
0.23ng/mL
特异性:
Natural and recombinant human 7,8-dihydro-8-oxoguanine triphosphatase
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human NUDT1 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤6.1%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤8.5%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

86

80-92

Plasma

88

82-94

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

100-113%

98-108%

95-104%

81-91%

EDTA plasma(n=5)

80-89%

111-123%

91-101%

84-93%

heparin plasma(n=5)

103-112%

 

102-112%

92-102%

95-105%

 

通用注释


亚单元:
Monomer.


功能:
Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.


亚细胞位置:
Isoform p26 Cytoplasm Mitochondrion matrix


该产品尚未在任何出版物中被引用。

[1].
"Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk."

[2].
"Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus."

[3].
"Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis."

[4].
"Association study of human MTH1 Ile45Thr polymorphism with sporadic Parkinson's disease."

[5].
"Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas."

[6].
"MYH, OGG1, MTH1, and APC alterations involved in the colorectal tumorigenesis of Korean patients with multiple adenomas."

[7].
"Genetic investigation of DNA-repair pathway genes PMS2, MLH1, MSH2, MSH6, MUTYH, OGG1 and MTH1 in sporadic colon cancer."

[8].
"Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis."

[9].
"The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal."

[10].
"Germline susceptibility to colorectal cancer due to base-excision repair gene defects."
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