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HTR6 (GeneName), 5-hydroxytryptamine receptor 6 (ProteinName), 5HT6R_HUMAN.
Product Name:

Human HTR6/ 5-hydroxytryptamine receptor 6 ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

5-HT-6, Serotonin receptor 6

Detection Method:
ELISA
Specificity:
Natural and recombinant human 5-hydroxytryptamine receptor 6
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human HTR6 ELISA Kit
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Human HTR6 ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with MTOR, RPTOR and NF1 (PubMed:23027611). Interacts with CDK5.


Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).


Subcellular Location:
Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Risperidone-related weight gain: genetic and nongenetic predictors."

[2].
"No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population."

[3].
"Serotonergic genes and personality traits in the Korean population."

[4].
"Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders."

[5].
"Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese."

[6].
"5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country."

[7].
"[Associations between six functional genes and schizophrenia]."

[8].
"Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia."

[9].
"Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function."

[10].
"Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease."
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