HTR6 (GeneName), 5-hydroxytryptamine receptor 6 (ProteinName), 5HT6R_HUMAN.
Human HTR6/ 5-hydroxytryptamine receptor 6 ELISA Kit
5-HT-6, Serotonin receptor 6
Natural and recombinant human 5-hydroxytryptamine receptor 6
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MTOR, RPTOR and NF1 (PubMed:23027611). Interacts with CDK5.
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611).
Cell membrane Multi-pass membrane protein
MVPEPGPTAN | STPAWGAGPP | SAPGGSGWVA | AALCVVIALT | AAANSLLIAL |
ICTQPALRNT | SNFFLVSLFT | SDLMVGLVVM | PPAMLNALYG | RWVLARGLCL |
LWTAFDVMCC | SASILNLCLI | SLDRYLLILS | PLRYKLRMTP | LRALALVLGA |
WSLAALASFL | PLLLGWHELG | HARPPVPGQC | RLLASLPFVL | VASGLTFFLP |
SGAICFTYCR | ILLAARKQAV | QVASLTTGMA | SQASETLQVP | RTPRPGVESA |
DSRRLATKHS | RKALKASLTL | GILLGMFFVT | WLPFFVANIV | QAVCDCISPG |
LFDVLTWLGY | CNSTMNPIIY | PLFMRDFKRA | LGRFLPCPRC | PRERQASLAS |
PSLRTSHSGP | RPGLSLQQVL | PLPLPPDSDS | DSDAGSGGSS | GLRLTAQLLL |
PGEATQDPPL | PTRAAAAVNF | FNIDPAEPEL | RPHPLGIPTN |
This product has not yet been referenced specifically in any publications.
"Risperidone-related weight gain: genetic and nongenetic predictors."
"No association of 5-HT2C, 5-HT6, and tryptophan hydroxylase-1 gene polymorphisms with personality traits in the Japanese population."
"Serotonergic genes and personality traits in the Korean population."
"Risperidone response and 5-HT6 receptor gene variance: genetic association analysis with adjustment for nongenetic confounders."
"Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese."
"5-Hydroxytryptamine 6 receptor (5-HT(6)) receptor and apolipoprotein E (ApoE) polymorphisms in patients with Alzheimer's disease in the Basque Country."
"[Associations between six functional genes and schizophrenia]."
"Lack of association between the T-->C 267 serotonin 5-HT6 receptor gene (HTR6) polymorphism and prediction of response to clozapine in schizophrenia."
"Serotonin 6 receptor polymorphism in schizophrenia: frequency, age at onset and cognitive function."
"Association analysis of HTR6 and HTR2A polymorphisms in sporadic Alzheimer's disease."
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