HTR4 (GeneName), 5-hydroxytryptamine receptor 4 (ProteinName), 5HT4R_HUMAN.
Human HTR4/ 5-hydroxytryptamine receptor 4 ELISA Kit
5-HT-4, Serotonin receptor 4
Natural and recombinant human 5-hydroxytryptamine receptor 4
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Isoform 5-HT4(A) interacts with MAGI2, MPP3, SLC9A3R1 and SNX27 isoforms 1 and 2. Isoform 5-HT4(E) interacts with PATJ, NOS1 and SEC23A. Isoform 5-HT4(A) forms a complex including SLC9A3R1 and EZR (By similarity). Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Cell membrane Multi-pass membrane protein Endosome Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
MDKLDANVSS | EEGFGSVEKV | VLLTFLSTVI | LMAILGNLLV | MVAVCWDRQL |
RKIKTNYFIV | SLAFADLLVS | VLVMPFGAIE | LVQDIWIYGE | VFCLVRTSLD |
VLLTTASIFH | LCCISLDRYY | AICCQPLVYR | NKMTPLRIAL | MLGGCWVIPT |
FISFLPIMQG | WNNIGIIDLI | EKRKFNQNSN | STYCVFMVNK | PYAITCSVVA |
FYIPFLLMVL | AYYRIYVTAK | EHAHQIQMLQ | RAGASSESRP | QSADQHSTHR |
MRTETKAAKT | LCIIMGCFCL | CWAPFFVTNI | VDPFIDYTVP | GQVWTAFLWL |
GYINSGLNPF | LYAFLNKSFR | RAFLIILCCD | DERYRRPSIL | GQTVPCSTTT |
INGSTHVLRD | AVECGGQWES | QCHPPATSPL | VAAQPSDT
This product has not yet been referenced specifically in any publications.
"Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia."
"Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus."
"Expression of serotonin receptor mRNAs in blood vessels."
"Association study of the serotoninergic system in migraine in the Spanish population."
"Lack of association between HTR4 gene polymorphisms and schizophrenia in case-control and family-based samples."
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