HTR3D (GeneName), 5-hydroxytryptamine receptor 3D (ProteinName), 5HT3D_HUMAN.
Human HTR3D/ 5-hydroxytryptamine receptor 3D ELISA Kit
5-HT3-D, Serotonin receptor 3D
Natural and recombinant human 5-hydroxytryptamine receptor 3D
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Cell membrane Multi-pass membrane protein Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
MQKHSPGPPA | LALLSQSLLT | TGNGDTLIIN | CPGFGQHRVD | PAAFQAVFDR |
KAIGPVTNYS | VATHVNISFT | LSAIWNCYSR | IHTFNCHHAR | PWHNQFVQWN |
PDECGGIKKS | GMATENLWLS | DVFIEESVDQ | TPAGLMASMS | IVKATSNTIS |
QCGWSASANW | TPSISPSMDR | ARAWRRMSRS | FQIHHRTSFR | TRREWVLLGI |
QKRTIKVTVA | TNQYEQAIFH | VAIRRRCRPS | PYVVNFLVPS | GILIAIDALS |
FYLPLESGNC | APFKMTVLLG | YSVFLLMMND | LLPATSTSSH | ASLVAPLALM |
QTPLPAGVYF | ALCLSLMVGS | LLETIFITHL | LHVATTQPLP | LPRWLHSLLL |
HCTGQGRCCP | TAPQKGNKGP | GLTPTHLPGV | KEPEVSAGQM | PGPGEAELTG |
GSEWTRAQRE | HEAQKQHSVE | LWVQFSHAMD | ALLFRLYLLF | MASSIITVIC |
This product has not yet been referenced specifically in any publications.
"Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E."
"Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy."
"A candidate gene study of obstructive sleep apnea in European Americans and African Americans."
"Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia."
"Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E."
"Architecture of the human interactome defines protein communities and disease networks."
"Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese."
"F-box only protein 9 is an E3 ubiquitin ligase of PPARγ."
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