HTR3C (GeneName), 5-hydroxytryptamine receptor 3C (ProteinName), 5HT3C_HUMAN.
Product Name:
Human HTR3C/ 5-hydroxytryptamine receptor 3C ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
5-HT3-C, Serotonin receptor 3C
Detection Method:
ELISA
Specificity:
Natural and recombinant human 5-hydroxytryptamine receptor 3C
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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General Annotation
Sub Unit:
Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.
Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Database link
UniGene:
SMR:
STRING:
KEGG:
MIM:
Pfam:
Uniprot:
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E."
[2].
"Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy."
[3].
"A candidate gene study of obstructive sleep apnea in European Americans and African Americans."
[5].
"Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia."
[6].
"Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy."
[7].
"Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy."
[8].
"Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E."
[9].
"The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance."
[10].
"Architecture of the human interactome defines protein communities and disease networks."
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