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HTR3C (GeneName), 5-hydroxytryptamine receptor 3C (ProteinName), 5HT3C_HUMAN.
Product Name:

Human HTR3C/ 5-hydroxytryptamine receptor 3C ELISA Kit

Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:

5-HT3-C, Serotonin receptor 3C

Detection Method:
ELISA
Specificity:
Natural and recombinant human 5-hydroxytryptamine receptor 3C
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Human HTR3C ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.


Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.


Subcellular Location:
Cell membrane Multi-pass membrane protein Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.


This product has not yet been referenced specifically in any publications.

[1].
"Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E."

[2].
"Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy."

[3].
"A candidate gene study of obstructive sleep apnea in European Americans and African Americans."

[4].
"Allelic variants in HTR3C show association with autism."

[5].
"Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia."

[6].
"Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy."

[7].
"Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy."

[8].
"Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E."

[9].
"The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance."

[10].
"Architecture of the human interactome defines protein communities and disease networks."
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