Htr3b (GeneName), 5-hydroxytryptamine receptor 3B (ProteinName), 5HT3B_RAT.
Rat Htr3b/ 5-hydroxytryptamine receptor 3B ELISA Kit
5-HT3-B, Serotonin receptor 3B
Natural and recombinant rat 5-hydroxytryptamine receptor 3B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B; homomeric complex is functional but exhibits low conductance with modified voltage dependence and antagonist affinity.
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Cell membrane Multi-pass membrane protein Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
MILLWSCLLV | AVVGILGTAT | PQPGNSSLHR | LTRQLLQQYH | KEVRPVYNWA |
EATTVYLDLC | VHAVLDVDVQ | NQKLKTSMWY | REVWNDEFLS | WNSSLFDDIQ |
EISLPLSAIW | APDIIINEFV | DVERSPDLPY | VYVNSSGTIR | NHKPIQVVSA |
CSLQTYAFPF | DIQNCSLTFN | SILHTVEDID | LGFLRNQEDI | ENDKRSFLND |
SEWQLLSVTS | TYHIRQSSAG | DFAQIRFNVV | IRRCPLAYVV | SLLIPSIFLM |
LVDLGSFYLP | PNCRARIVFK | TNVLVGYTVF | RVNMSDEVPR | SAGCTSLIGV |
FFTVCMALLV | LSLSKSILLI | KFLYEERHSE | QERPLMCLRG | DSDANESRLY |
LRAPCAEDTE | SPVRQEHQVP | SDTLKDFWFQ | LQSINNSLRT | RDQVYQKEVE |
WLAILCHFDQ | LLFRIYLAVL | GLYTVTLCSL | WALWSRM
This product has not yet been referenced specifically in any publications.
"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."
"The 5-HT3B subunit is a major determinant of serotonin-receptor function."
"The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."
"Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders."
"Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea."
"An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population."
"Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine."
"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."
"Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists."
"Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients."
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