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Htr3b (GeneName), 5-hydroxytryptamine receptor 3B (ProteinName), 5HT3B_MOUSE.

Product Name:

Mouse Htr3b/ 5-hydroxytryptamine receptor 3B ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

5-HT3-B, Serotonin receptor 3B

Detection Method:

ELISA

Specificity:

Natural and recombinant mouse 5-hydroxytryptamine receptor 3B

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Mouse Htr3b ELISA Kit

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Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Forms a pentaheteromeric complex with HTR3A. Not functional as a homomeric complex.

Function:

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Subcellular Location:

Cell membrane Multi-pass membrane protein Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.

Database link

UniGene:

Mm.117131

STRING:

10090.ENSMUSP00000008734

KEGG:

mmu:57014

Pfam:

PF02931

Uniprot:

Q9JHJ5

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Sequence length:

437

Sequence:

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400:

437:

WLAILYRFDQ | LLFRIYLAVL | GLYTVTLCSL | WALWSRM

3D Model:

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."

(PMID: 15293096)

[2].

"The 5-HT3B subunit is a major determinant of serotonin-receptor function."

(PMID: 9950429)

[3].

"The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit."

(PMID: 10521471)

[4].

"Functional variants of the serotonin receptor type 3A and B gene are associated with eating disorders."

(PMID: 19741568)

[5].

"Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea."

(PMID: 17697394)

[6].

"An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population."

(PMID: 18807291)

[7].

"Tissue-specific alternative promoters of the serotonin receptor gene HTR3B in human brain and intestine."

(PMID: 17010535)

[8].

"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."

(PMID: 16487942)

[9].

"Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists."

(PMID: 15115912)

[10].

"Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients."

(PMID: 15389765)

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