Home > ELISA Kit > Rat Htr3a ELISA Kit

Htr3a (GeneName), 5-hydroxytryptamine receptor 3A (ProteinName), 5HT3A_RAT.

Product Name:

Rat Htr3a/ 5-hydroxytryptamine receptor 3A ELISA Kit

Cat.#:

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

5-HT3-A, 5-hydroxytryptamine receptor 3, 5-HT-3, Serotonin receptor 3A, Serotonin-gated ion channel receptor, 5ht3, Htr3

Detection Method:

ELISA

Specificity:

Natural and recombinant rat 5-hydroxytryptamine receptor 3A

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Research Area:

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Rat Htr3a ELISA Kit

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Product Datasheets

Data
Citations
Publication
Sequence / 3D
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General Annotation

Sub Unit:

Interacts with RIC3 (By similarity). Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B; homomeric complex is functional but exhibits low conductance with modified voltage dependence and antagonist affinity.

Function:

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.

Subcellular Location:

Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Database link

UniGene:

Rn.55109

SMR:

P35563

STRING:

10116.ENSRNOP00000008965

KEGG:

rno:79246

Pfam:

PF02931

Uniprot:

P35563

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Sequence length:

483

Sequence:

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483:

GYVLDRLLFR | IYLLAVLAYS | ITLVTLWSIW | HYS

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."

(PMID: 12867984)

[2].

"Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients."

(PMID: 18622264)

[3].

"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."

(PMID: 16487942)

[4].

"Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."

(PMID: 15809299)

[5].

"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."

(PMID: 15293096)

[6].

"A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women."

(PMID: 14557147)

[7].

"Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response."

(PMID: 12363396)

[8].

"Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species."

(PMID: 7565620)

[9].

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."

(PMID: 20628086)

[10].

"Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?"

(PMID: 20602615)

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