Htr3a (GeneName), 5-hydroxytryptamine receptor 3A (ProteinName), 5HT3A_MOUSE.
Mouse Htr3a/ 5-hydroxytryptamine receptor 3A ELISA Kit
5-HT3-A, 5-hydroxytryptamine receptor 3, 5-HT-3, Serotonin receptor 3A, Serotonin-gated ion channel receptor, 5ht3, Htr3
Natural and recombinant mouse 5-hydroxytryptamine receptor 3A
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B; homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Interacts with RIC3.
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
MRLCIPQVLL | ALFLSMLTAP | GEGSRRRATQ | EDTTQPALLR | LSDHLLANYK |
KGVRPVRDWR | KPTTVSIDVI | MYAILNVDEK | NQVLTTYIWY | RQYWTDEFLQ |
WTPEDFDNVT | KLSIPTDSIW | VPDILINEFV | DVGKSPNIPY | VYVHHRGEVQ |
NYKPLQLVTA | CSLDIYNFPF | DVQNCSLTFT | SWLHTIQDIN | ITLWRSPEEV |
RSDKSIFINQ | GEWELLEVFP | QFKEFSIDIS | NSYAEMKFYV | IIRRRPLFYA |
VSLLLPSIFL | MVVDIVGFCL | PPDSGERVSF | KITLLLGYSV | FLIIVSDTLP |
ATIGTPLIGV | YFVVCMALLV | ISLAETIFIV | RLVHKQDLQR | PVPDWLRHLV |
LDRIAWILCL | GEQPMAHRPP | ATFQANKTDD | CSGSDLLPAM | GNHCSHVGGP |
QDLEKTPRGR | GSPLPPPREA | SLAVRGLLQE | LSSIRHFLEK | RDEMREVARD |
WLRVGYVLDR | LLFRIYLLAV | LAYSITLVTL | WSIWHYS
This product has not yet been referenced specifically in any publications.
"A cytoplasmic region determines single-channel conductance in 5-HT3 receptors."
"Association between a polymorphism of the HTR3A gene and therapeutic response to risperidone treatment in drug-naive Chinese schizophrenia patients."
"Distinguishable haplotype blocks in the HTR3A and HTR3B region in the Japanese reveal evidence of association of HTR3B with female major depression."
"Cell surface expression of 5-hydroxytryptamine type 3 receptors is promoted by RIC-3."
"Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients."
"A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women."
"Novel mutations in 5-HT3A and 5-HT3B receptor genes not associated with clozapine response."
"Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?"
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