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Htr2c (GeneName), 5-hydroxytryptamine receptor 2C (ProteinName), 5HT2C_MOUSE.
Product Name:

Mouse Htr2c/ 5-hydroxytryptamine receptor 2C ELISA Kit

Cat.#:

E10285m

Brand:
EIAab®
Regulatory Status:
Alternative:

5-HT-2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, Serotonin receptor 2C, 5ht1c, Htr1c

Detection Method:
ELISA
Specificity:
Natural and recombinant mouse 5-hydroxytryptamine receptor 2C
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
Mouse Htr2c ELISA Kit
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Product Datasheets


General Annotation


Sub Unit:
Interacts with MPDZ. Interacts with ARRB2.


Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.


Subcellular Location:
Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."

[2].
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."

[3].
"Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder."

[4].
"Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain."

[5].
"Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample."
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