Htr2c (GeneName), 5-hydroxytryptamine receptor 2C (ProteinName), 5HT2C_MOUSE.
Mouse Htr2c/ 5-hydroxytryptamine receptor 2C ELISA Kit
5-HT-2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, Serotonin receptor 2C, 5ht1c, Htr1c
Natural and recombinant mouse 5-hydroxytryptamine receptor 2C
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts with MPDZ. Interacts with ARRB2.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and feeding behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.
Cell membrane Multi-pass membrane protein
MVNLGTAVRS | LLVHLIGLLV | WQFDISISPV | AAIVTDTFNS | SDGGRLFQFP |
DGVQNWPALS | IVVIIIMTIG | GNILVIMAVS | MEKKLHNATN | YFLMSLAIAD |
MLVGLLVMPL | SLLAILYDYV | WPLPRYLCPV | WISLDVLFST | ASIMHLCAIS |
LDRYVAIRNP | IEHSRFNSRT | KAIMKIAIVW | AISIGVSVPI | PVIGLRDESK |
VFVNNTTCVL | NDPNFVLIGS | FVAFFIPLTI | MVITYFLTIY | VLRRQTLMLL |
RGHTEEELRN | ISLNFLKCCC | KKGDEEENAP | NPNPDQKPRR | KKKEKRPRGT |
MQAINNEKKA | SKVLGIVFFV | FLIMWCPFFI | TNILSVLCGK | ACNQKLMEKL |
LNVFVWIGYV | CSGINPLVYT | LFNKIYRRAF | SKYLRCDYKP | DKKPPVRQIP |
RVAATALSGR | ELNVNIYRHT | NERVVRKAND | TEPGIEMQVE | NLELPVNPSN |
This product has not yet been referenced specifically in any publications.
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."
"Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder."
"Mutation screening and assessment of the effect of genetic variations on expression and RNA editing of serotonin receptor 2C in the human brain."
"Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample."
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