Htr2b (GeneName), 5-hydroxytryptamine receptor 2B (ProteinName), 5HT2B_MOUSE.
Product Name:
Mouse Htr2b/ 5-hydroxytryptamine receptor 2B ELISA Kit
Cat.#:
-
Brand:
EIAab®
Regulatory Status:
Alternative:
5-HT-2B, 5-HT-2F, NP75 protein, Serotonin receptor 2B
Detection Method:
ELISA
Specificity:
Natural and recombinant mouse 5-hydroxytryptamine receptor 2B
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
- Feedback Wall (0)
General Annotation
Sub Unit:
Interacts (via C-terminus) with MPDZ.
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1426253). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:1426253, PubMed:16940156). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and downstream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (PubMed:16940156, PubMed:18337424). May play a role in the perception of pain (PubMed:21273425). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (PubMed:10944220, PubMed:11413089). Protects cardiomyocytes against apoptosis (PubMed:12738797). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (PubMed:12244304). Plays a role in vasoconstriction (PubMed:12244304, PubMed:23346101). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (PubMed:17846081). Required for normal proliferation of the interstitial cells of Cajal in the intestine (PubMed:19941613).
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cell junction
Synapse
Synaptosome
Database link
Valid Sequence:
This product has not yet been referenced specifically in any publications.
[1].
"Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells."
[2].
"Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy."
[3].
"5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells."
[4].
"Cloning and functional characterization of the human 5-HT2B serotonin receptor."
[5].
"The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors."
[8].
"Association study of the serotoninergic system in migraine in the Spanish population."
[9].
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
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