Htr2b (GeneName), 5-hydroxytryptamine receptor 2B (ProteinName), 5HT2B_MOUSE.
Mouse Htr2b/ 5-hydroxytryptamine receptor 2B ELISA Kit
5-HT-2B, 5-HT-2F, NP75 protein, Serotonin receptor 2B
Natural and recombinant mouse 5-hydroxytryptamine receptor 2B
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts (via C-terminus) with MPDZ.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1426253). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:1426253, PubMed:16940156). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and downstream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (PubMed:16940156, PubMed:18337424). May play a role in the perception of pain (PubMed:21273425). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (PubMed:10944220, PubMed:11413089). Protects cardiomyocytes against apoptosis (PubMed:12738797). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (PubMed:12244304). Plays a role in vasoconstriction (PubMed:12244304, PubMed:23346101). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (PubMed:17846081). Required for normal proliferation of the interstitial cells of Cajal in the intestine (PubMed:19941613).
Cell membrane Multi-pass membrane protein Cell junction Synapse Synaptosome
MASSYKMSEQ | STTSEHILQK | TCDHLILTNR | SGLETDSVAE | EMKQTVEGQG |
HTVHWAALLI | LAVIIPTIGG | NILVILAVAL | EKRLQYATNY | FLMSLAIADL |
LVGLFVMPIA | LLTIMFEAIW | PLPLALCPAW | LFLDVLFSTA | SIMHLCAISL |
DRYIAIKKPI | QANQCNSRAT | AFIKITVVWL | ISIGIAIPVP | IKGIETDVIN |
PHNVTCELTK | DRFGSFMVFG | SLAAFFAPLT | IMVVTYFLTI | HTLQKKAYLV |
KNKPPQRLTR | WTVPTVFLRE | DSSFSSPEKV | AMLDGSHRDK | ILPNSSDETL |
MRRMSSVGKR | SAQTISNEQR | ASKALGVVFF | LFLLMWCPFF | ITNLTLALCD |
SCNQTTLKTL | LEIFVWIGYV | SSGVNPLIYT | LFNKTFREAF | GRYITCNYRA |
TKSVKALRKF | SSTLCFGNSM | VENSKFFTKH | GIRNGINPAM | YQSPMRLRSS |
TIQSSSIILL | DTLLTENDGD | KAEEQVSYI
This product has not yet been referenced specifically in any publications.
"Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells."
"Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy."
"5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells."
"Cloning and functional characterization of the human 5-HT2B serotonin receptor."
"The human serotonin 5-HT2B receptor: pharmacological link between 5-HT2 and 5-HT1D receptors."
"Crystal Structure of an LSD-Bound Human Serotonin Receptor."
"Structural features for functional selectivity at serotonin receptors."
"Association study of the serotoninergic system in migraine in the Spanish population."
"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study."
"A population-specific HTR2B stop codon predisposes to severe impulsivity."
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