Htr2a (GeneName), 5-hydroxytryptamine receptor 2A (ProteinName), 5HT2A_RAT.
Product Name:
Rat Htr2a/ 5-hydroxytryptamine receptor 2A ELISA Kit
Cat.#:
E10283r
Brand:
EIAab®
Regulatory Status:
Alternative:
5-HT-2, Serotonin receptor 2A, Htr2
Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.081 ng/mL
Specificity:
Natural and recombinant rat 5-hydroxytryptamine receptor 2A
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:

Research Area:
-
- Data
- Citations
- Publication
- Sequence / 3D
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Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of 5-hydroxytryptamine receptor 2A and their serial dilutions.
The results were demonstrated by the percentage of calculated concentration to the expected.
Sample |
1:2 |
1:4 |
1:8 |
1:16 |
serum(n=5) |
97-109% |
108-117% |
97-106% |
90-100% |
EDTA plasma(n=5) |
95-95% |
101-111% |
91-101% |
106-118% |
heparin plasma(n=5) |
103-113%
|
99-109% |
80-80% |
97-110% |
General Annotation
Sub Unit:
Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.
Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cell projection
Axon
Cytoplasmic vesicle
Membrane
Caveola
Cell projection
Dendrite
Localizes to the postsynaptic thickening of axo-dendritic synapses.
This product has not yet been referenced specifically in any publications.
[1].
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."
[2].
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."
[3].
"Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment."
[4].
"Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder."
[5].
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."
[6].
"Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study."
[7].
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."
[8].
"HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients."
[9].
"Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients."
[10].
"Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes."
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