Home > ELISA Kit > Rat Htr2a ELISA Kit

Htr2a (GeneName), 5-hydroxytryptamine receptor 2A (ProteinName), 5HT2A_RAT.

Product Name:

Rat Htr2a/ 5-hydroxytryptamine receptor 2A ELISA Kit

Cat.#:

E10283r

Brand:

EIAab^®

Regulatory Status:

RUO

Alternative:

5-HT-2, Serotonin receptor 2A, Htr2

Detection Method:

ELISA

Assay Type:

Sandwich

Detection Range:

0.156-10ng/mL

Sensitivity:

0.081 ng/mL

Specificity:

Natural and recombinant rat 5-hydroxytryptamine receptor 2A

Sample Type:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

Sample Data:

Assay Procedure:

Research Area:

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Rat Htr2a ELISA Kit

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Product Datasheets

Instruction:

MSDS:

Data
Citations
Publication
Sequence / 3D
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Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of 5-hydroxytryptamine receptor 2A and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	97-109%	108-117%	97-106%	90-100%
EDTA plasma(n=5)	95-95%	101-111%	91-101%	106-118%
heparin plasma(n=5)	103-113%	99-109%	80-80%	97-110%

General Annotation

Sub Unit:

Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.

Function:

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell projection Axon Cytoplasmic vesicle Membrane Caveola Cell projection Dendrite Localizes to the postsynaptic thickening of axo-dendritic synapses.

Database link

UniGene:

Rn.10294

SMR:

P14842

STRING:

10116.ENSRNOP00000013408

KEGG:

rno:29595

Pfam:

PF00001

Uniprot:

P14842

Related Product

Human HTR2A ELISA Kit

Mouse Htr2a ELISA Kit

Bovine HTR2A ELISA Kit

Pig HTR2A ELISA Kit

Dog HTR2A ELISA Kit

Sequence length:

471

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

471:

QQSEENCTDN | IETVNEKVSC | V

3D Structure:

Predicted Epitope:

Valid Sequence:

This product has not yet been referenced specifically in any publications.

[1].

"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."

(PMID: 20071033)

[2].

"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."

(PMID: 20010450)

[3].

"Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment."

(PMID: 19924111)

[4].

"Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder."

(PMID: 19095219)

[5].

"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."

(PMID: 19560507)

[6].

"Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study."

(PMID: 19032968)

[7].

"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."

(PMID: 19077664)

[8].

"HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients."

(PMID: 19387614)

[9].

"Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients."

(PMID: 19855357)

[10].

"Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes."

(PMID: 19647026)

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