HTR2A (GeneName), 5-hydroxytryptamine receptor 2A (ProteinName), 5HT2A_PIG.
Pig HTR2A/ 5-hydroxytryptamine receptor 2A ELISA Kit
5-HT-2, Serotonin receptor 2A
Natural and recombinant pig 5-hydroxytryptamine receptor 2A
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Interacts (via C-terminus) with MPDZ and PATJ. May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2. Interacts with GRM2 and DRD2; this may affect signaling.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Cell membrane Multi-pass membrane protein Cell projection Axon Cytoplasmic vesicle Membrane Caveola Cell projection Dendrite Localizes to the postsynaptic thickening of axo-dendritic synapses.
MDVLCEENTS | LSSPTNSFMQ | LNDDTRLYHN | DFNSGEANTS | DAFNWTVDSE |
NRTNLSCEGC | LSPPCFSLLH | LQEKNWSALL | TAVVIILTIA | GNILVIMAVS |
LEKKLQNATN | YFLMSLAIAD | MLLGFLVMPV | SMLTILYGYR | WPLPSKLCAV |
WIYLDVLFST | ASIMHLCAIS | LDRYVAIQNP | IHHRRFNSRT | KAFLKIIAVW |
TISVGISMPI | PVFGLQDDSK | VFKEGSCLLA | DDNFVLIGSF | VSFFIPLTIM |
VITYFLTIKS | LQKEATLCVS | DLGTRAKLAS | FSFLPQSSLS | SEKLFQRSIH |
REPGSYGRRT | MQSISNEQKA | CKVLGIVFFL | FVVMWCPFFI | TNIMAVICKE |
SCNEDVIGAL | LNVFVWIGYL | SSAVNPLVYT | LFNKTYRSAF | SRYIQCQYKE |
NKKPLQLILV | NTIPALAYKS | SQLQTGQKEN | SKQDDKATEN | DCTMVALGKQ |
HSEDAPADNS | NTVNEKVSCV |
This product has not yet been referenced specifically in any publications.
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."
"Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment."
"Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder."
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."
"Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study."
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."
"HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients."
"Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients."
"Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes."
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