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HTR2A (GeneName), 5-hydroxytryptamine receptor 2A (ProteinName), 5HT2A_HUMAN.
Product Name:

Human HTR2A/ 5-hydroxytryptamine receptor 2A ELISA Kit

Cat.#:

E10283h

Brand:
EIAab®
Regulatory Status:
Alternative:

5-HT-2, Serotonin receptor 2A, HTR2

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.156-10ng/mL
Sensitivity:
0.087ng/mL
Specificity:
Natural and recombinant human 5-hydroxytryptamine receptor 2A
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
-
Human HTR2A ELISA Kit
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Human HTR2A ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of 5-hydroxytryptamine receptor 2A and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

110-120%

98-108%

108-117%

107-117%

EDTA plasma(n=5)

91-101%

113-122%

105-115%

80-80%

heparin plasma(n=5)

108-117%

 

104-114%

89-98%

106-116%

 

General Annotation


Sub Unit:
Interacts (via C-terminus) with MPDZ and PATJ (PubMed:11150294, PubMed:14988405). May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (PubMed:14988405). Interacts with GRM2 and DRD2; this may affect signaling (PubMed:18297054, PubMed:21645528, PubMed:22300836).


Function:
(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV.


Subcellular Location:
Cell membrane Multi-pass membrane protein Cell projection Dendrite Cell projection Axon Cytoplasmic vesicle Membrane Caveola Localizes to the postsynaptic thickening of axo-dendritic synapses.


This product has not yet been referenced specifically in any publications.

[1].
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."

[2].
"A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome."

[3].
"Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment."

[4].
"Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder."

[5].
"Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder."

[6].
"Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study."

[7].
"Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response."

[8].
"HTR2A A-1438G/T102C polymorphisms predict negative symptoms performance upon aripiprazole treatment in schizophrenic patients."

[9].
"Serotonin receptor 2A gene polymorphisms and schizophrenia: association with family history, diagnostic subtype and height in patients."

[10].
"Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes."
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