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Htr1b (GeneName), 5-hydroxytryptamine receptor 1B (ProteinName), 5HT1B_RAT.
Product Name:

Rat Htr1b/ 5-hydroxytryptamine receptor 1B ELISA Kit

Cat.#:

E10279r

Brand:
EIAab®
Regulatory Status:
Alternative:

5-HT-1B, Serotonin receptor 1B, 5ht1b

Detection Method:
ELISA
Assay Type:
Sandwich
Detection Range:
0.312-20ng/mL
Sensitivity:
0.115ng/mL
Specificity:
Natural and recombinant rat 5-hydroxytryptamine receptor 1B
Sample Type:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
Sample Data:
Assay Procedure:
Assay Procedure
Research Area:
-
Rat Htr1b ELISA Kit
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Rat Htr1b ELISA Kit
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Product Datasheets
Instruction: Down Instruction
MSDS: MSDS


Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.6%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤5.6%

Recovery
Recovery was determined by spiking various levels of 5-hydroxytryptamine receptor 1B into serum and plasma.

Sample Type

Average(%)

Recovery Range(%)

Serum

99

93-105

Plasma

101

95-107

 

 

 

 

Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of 5-hydroxytryptamine receptor 1B and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample

1:2

1:4

1:8

1:16

serum(n=5)

95-105%

93-104%

108-118%

109-120%

EDTA plasma(n=5)

105-113%

88-100%

103-113%

88-101%

heparin plasma(n=5)

106-116%

 

100-109%

106-116%

99-112%

 

General Annotation


Sub Unit:
Homodimer. Heterodimer with HTR1D.


Function:
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.


Subcellular Location:
Cell membrane Multi-pass membrane protein


This product has not yet been referenced specifically in any publications.

[1].
"Lack of association between five serotonin metabolism-related genes and medication overuse headache."

[2].
"[Association study of HTR1A and HTR1B with adolescent idiopathic scoliosis]."

[3].
"Comorbidity between bipolar disorder and alcohol use disorder: association of dopamine and serotonin gene polymorphisms."

[4].
"Fluoxetine response in impulsive-aggressive behavior and serotonin transporter polymorphism in personality disorder."

[5].
"Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men."

[6].
"SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A."

[7].
"An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population."

[8].
"Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in Borderline personality disorder."

[9].
"The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence."

[10].
"HTR1B and HTR2C in autism spectrum disorders in Brazilian families."
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